SIGNAL PROCESSING CORE
A novel algorithm to reconstruct X-ray tomograms reduces radiation exposure
In collaboration with Marco Stampanoni’s team (phase-contrast x-ray imaging), SP has developed a novel mathematical formulation to reconstruct tomograms. The new algorithm was implemented and perfected by Masih Nilchian (SP); while visiting the PSI, he was able to demonstrate that it produces images of better quality than the method previously used at the PSI. It is also substantially more robust and can handle much harder scenarios with fewer views. The acquisition time and radiation exposure can be reduced by a factor of four (or more) without compromise in quality. The results are so promising that the computational method has been incorporated into the reconstruction pipeline of TOmographic Microscopy and Coherent rAdiology experimentTs (TOMCAT) at the PSI.
Targeted chemotherapeutic compounds for treatment of breast cancer
Prof. Yann Seimbille
The project “A theranostic approach towards targeted chemotherapy delivery by RGD-conjugated cytotoxic compounds” received the 2014 Leenaards award for scienti c research. Initiated by Dr. Anita Wolfer (CHUV) with Prof. Elena Dubikovskaya (EPFL) and Prof. Yann Seimbille (UniGE), the project aims toward the development of targeted delivery of therapeutic compounds for treatment of breast cancer. In vivo PET evaluation of biodistribution and pharmacodynamics of these novel compounds in tumor bearing mice will provide important information for early clinical trials.
CHUV 3T MR CORE
Non-invasive in vivo detection of cardiovascular pathologies
Dr. Ruud van Heeswijk
At its inception, CIBM-CHUV-MR pioneered uorine molecular MRI for the visualization of in ammation. This critically enabled the non- invasive in vivo detection of myocarditis and led to the prestigious P zer Research Prize bestowed to Dr. Ruud van Heeswijk. Building on this initial success, detection of atherosclerotic lesions in the arterial wall became possible as a next step and culminated in a successful SNSF Ambizione grant application aimed at translation of these intriguing ndings.
HUG 3T MR CORE
A long lasting collaboration with neonatology department at HUG
Collaboration with the neonathalogie department, HUG
The CIBM has a long lasting collaboration with the service of neonatology for the study of early brain development. The main goal is to develop early biomarkers to assess risk factors for developing diseases such as autism, cognitive retardation or growth retardation that could be associated with prematurity. There are many challenges to perform advanced MRI examination in the newborn, and the CIBM contributes signi cantly to the development of speci c tools for structural and functional neuro- connectivity as well as in quantitative brain analysis.
Noninvasive measurement of metabolic impairments linked to diseases
Prof. Arnaud Comment
Hyperpolarization allows boosting the sensitivity of magnetic resonance for detecting metabolism in vivo in real time a er the administration of substances such as sugar molecules. We implemented the world most sensitive setup for biomedical applications and proposed a method to avoid the use of exogenous chemicals by simply exposing sugar molecules to UV light at low temperature. Using this straightforward method it is possible to noninvasively measure metabolic impairments linked to diseases.